Apa Manfaat Kesehatan Dan Kegunaan Minyak Cengkeh?

Daftar Isi:

Video: Apa Manfaat Kesehatan Dan Kegunaan Minyak Cengkeh?

Video: Apa Manfaat Kesehatan Dan Kegunaan Minyak Cengkeh?
Video: MENAKJUBKAN!! Inilah 24 Manfaat Minyak Cengkeh Bagi Kesehatan 2024, Mungkin
Apa Manfaat Kesehatan Dan Kegunaan Minyak Cengkeh?
Apa Manfaat Kesehatan Dan Kegunaan Minyak Cengkeh?
Anonim

Minyak cengkeh diekstrak dari pohon cengkeh. Ini adalah uap yang disuling dari tunas cengkeh yang memiliki bau menyengat yang tajam. Ini asli Asia Tenggara dan telah digunakan untuk mengobati rasa sakit yang terkait dengan masalah gigi selama berabad-abad.

Minyak cengkeh dikatakan memiliki sifat antioksidan, antimikroba, antijamur, antiinflamasi, dan anestesi (1), (2). Ini juga dapat membantu mengobati penyakit kulit, membantu pencernaan, dan meningkatkan sistem kekebalan tubuh. Artikel ini membahas tentang potensi manfaat kesehatan, kegunaan, dan efek samping minyak cengkih. Baca terus untuk mengetahui lebih lanjut.

Daftar Isi

  • 12 Kegunaan Dan Manfaat Minyak Cengkeh
  • Penggunaan Minyak Cengkih Lainnya
  • Bagaimana Cara Menggunakan Minyak Cengkih Untuk Mengobati Sakit Gigi?
  • Bagaimana Anda Menggunakan Minyak Cengkih Untuk Pertumbuhan Rambut?
  • Apakah Ada Efek Samping Penggunaan Minyak Cengkih?
  • Yang Harus Diperhatikan Saat Membeli Minyak Cengkih

12 Kegunaan Dan Manfaat Minyak Cengkeh

1. Dapat Meredakan Sakit Gigi

Minyak esensial cengkih dapat membantu mencegah gigi berlubang dan meredakan nyeri mulut. Secara tradisional, ini digunakan untuk meredakan sakit gigi. Ini juga digunakan untuk keadaan darurat gigi seperti radang mulut atau tenggorokan. Minyak cengkeh juga telah dilaporkan digunakan dalam pembuatan pasta gigi dan obat kumur tertentu (3). Eugenol, cairan berminyak aromatik yang diekstrak dari minyak cengkeh, digunakan sebagai obat penenang dalam prosedur gigi (4). Cengkeh juga memiliki sifat anti plak. Ini dapat menghambat pertumbuhan bakteri mulut yang dapat menyebabkan plak gigi (5).

Minyak esensial cengkeh juga ditemukan menunjukkan aktivitas antikariogenik dan sitotoksik terhadap sejumlah besar patogen oral (6). Eugenol dan eugenyl acetate adalah dua komponen aktif dalam minyak atsiri cengkeh yang membantu mencegah dekalsifikasi atau erosi gigi (7). Minyak cengkeh paling efektif melawan mikroorganisme penyebab karies gigi (8).

2. Dapat Membantu Mengobati Penyakit Kulit Dan Jerawat

Minyak cengkeh dikatakan bertindak melawan Propionibacterium acnes, bakteri penyebab jerawat (9). Namun, penelitian lebih lanjut di baris ini diperlukan untuk mencapai kesimpulan lebih lanjut.

Sebuah penelitian yang dilakukan oleh Departemen Dermatologi, Kairo, Mesir menemukan bahwa minyak cengkeh efektif dalam pengobatan topikal pruritus kronis (10).

Studi lain yang dilakukan oleh Mansoura University Hospital, Mesir, menemukan bahwa penggunaan krim minyak cengkih secara topikal dapat membantu dalam pengobatan fisura anus kronis (11).

3. Mungkin Memiliki Sifat Analgesik

Pijat minyak cengkeh terbukti efektif mengurangi sakit punggung pada ibu pasca melahirkan (12). Minyak cengkih dikatakan memiliki sifat analgesik yang mengurangi sakit gigi dan nyeri sendi dengan mengaktifkan saluran kalsium dan klorida di kelenjar getah bening (13). Eugenol dalam cengkeh juga telah dipelajari untuk efek analgesiknya (14). Minyak cengkih juga bisa meredakan nyeri pada tikus (15).

Studi lain yang dilakukan oleh Universitas Kuwait menemukan bahwa gel cengkeh mungkin memiliki potensi untuk menggantikan benzocaine sebagai anestesi topikal (16).

4. Dapat Membantu Pencernaan

Minyak cengkih dapat membantu meredakan mual, muntah, dan mabuk perjalanan, berkat sifat antiirrit dan menenangkannya (17). Eugenol dalam minyak atsiri cengkeh memiliki kemampuan untuk merangsang sintesis lendir, faktor gastroprotektif yang penting (18). Namun, penelitian lebih lanjut diperlukan untuk memahami penggunaannya dalam pengobatan tukak lambung.

5. Dapat Meningkatkan Sistem Kekebalan Tubuh

Eugenol dalam cengkeh melindungi membran sel dari kerusakan akibat radikal bebas dan stres oksidatif (19). Dalam satu penelitian pada hewan, minyak juga bisa memberikan peran perlindungan terhadap stres oksidatif yang diinduksi radiasi (20). Minyak cengkeh dikatakan memiliki efek antiinflamasi. Sebuah penelitian menunjukkan minyak cengkeh memiliki efek antiinflamasi yang bergantung pada dosis pada tikus Wistar (21). Juga, minyak ditemukan memiliki efek antinociceptive dan antipiretik pada tikus (22).

6. Mungkin Memiliki Sifat Antimikroba

Minyak atsiri cengkeh adalah sumber senyawa antimikroba yang ampuh yang terutama bertindak melawan bakteri patogen (23). Minyak ini efektif dalam menghentikan pertumbuhan beberapa jenis bakteri dan juga melawan patogen saluran pernapasan (24). Minyak cengkeh juga ditemukan bertindak melawan strain klinis kumparan Escherichia, bakteri spesifik yang sangat resisten terhadap beberapa antibiotik (25). Sebuah studi yang dilakukan oleh Bagian Mikrobiologi dan Teknologi Makanan Laut, Spanyol, menemukan bahwa minyak esensial cengkeh secara efisien membunuh biofilm Staphylococcus aureus (26).

Selain itu, minyak cengkeh bekerja melawan Candida albicans yang menyebabkan sariawan, kutu air, dan infeksi jamur vagina. Eugenol dalam minyak cengkeh dapat memberikan efek anticandidal (27). Sebuah penelitian yang dilakukan oleh Toyama Medical and Pharmaceutical University menemukan bahwa kombinasi asiklovir Sebuah penelitian yang dilakukan oleh Toyama Medical and Pharmaceutical University menemukan bahwa kombinasi asiklovir (obat antivirus) dan cengkih pada tikus dapat mengobati infeksi virus herpes simpleks (28). Campuran minyak esensial dengan minyak cengkih dapat secara signifikan mengurangi virus influenza. Virus yang diobati dengan campuran minyak memiliki ekspresi protein virus yang minimal. Ini berarti minyak cengkeh memiliki kemampuan untuk melawan virus tertentu yang menyebabkan infeksi (29).

7. Dapat Bertindak Sebagai Pengusir Serangga

Minyak cengkeh dapat bertindak sebagai pengusir serangga dan mencegah penyakit yang ditularkan melalui vektor (yang disebabkan oleh parasit pada manusia) (30). Sebuah penelitian menemukan bahwa komponen minyak esensial cengkeh berpotensi berguna dalam produksi pengusir kutu tubuh (31). Minyak cengkeh juga bisa menunjukkan aktivitas pengusir rayap Jepang (32).

Sebuah studi yang dilakukan oleh Mahidol University, Thailand, menemukan bahwa essentialoil cengkeh dapat mengusir chiggers Leptotrombidium yang merupakan salah satu spesies larva. Minyak juga bisa menjadi alternatif yang lebih aman dan lebih murah untuk penolak sintetis yang dapat menyebabkan efek samping (33). Minyak atsiri cengkeh juga menunjukkan daya tahan terhadap Leptotrombidium deliense, spesies larva lain (34). Selain itu, formulasi yang mengandung minyak esensial cengkeh terbukti efektif melawan nyamuk Aedes aegypti (35).

Eugenol dalam minyak cengkeh juga bisa bekerja sebagai alternatif yang menjanjikan untuk insektisida umum (36). Eugenol, eugenol acetate, dan beta-caryophyllene, bahan kimia bioaktif dalam cengkeh, ditemukan memiliki kemampuan untuk mengusir semut api merah (37).

8. Dapat Mengurangi Sakit Perut

Eugenol dalam minyak cengkeh telah terbukti bermanfaat untuk mengatasi keluhan gastrointestinal, seperti sakit perut. Ini juga digunakan untuk mengobati batuk, dahak, dan sesak dada (38). Cengkeh bisa digunakan untuk mengurangi sakit perut. Namun, data terbatas tersedia untuk mendukung klaim ini.

9. Dapat Meningkatkan Kesehatan Kardiovaskular

Minyak cengkih dapat membantu meningkatkan kesehatan jantung. Secara tradisional, ini dikenal untuk meningkatkan sirkulasi darah. Sebuah penelitian pada tikus menunjukkan bahwa eugenol dalam minyak melebarkan arteri serebral. Ini, pada manusia, dapat berarti penurunan risiko stroke (39). Pada tikus, pengobatan dengan eugenol dapat menurunkan tingkat tekanan darah dan bahkan memperlambat detak jantung (40). Dalam penelitian lain, tikus yang diberi makan fruktosa tinggi, ketika diberi minyak esensial cengkeh, menunjukkan peningkatan pada perlemakan hati. Minyak juga bisa mengatur kadar kolesterol pada tikus. Studi ini menunjukkan kemungkinan sifat kardioprotektif minyak cengkih (41).

Pada tikus diabetes, minyak cengkih juga bisa menunjukkan efek kardioprotektif. Ini bisa jadi karena sifat antioksidan minyaknya (42). Studi lain menyimpulkan bahwa eugenol dapat bermanfaat secara terapeutik sebagai agen antihipertensi (43).

10. Dapat Meningkatkan Pertumbuhan Rambut

Eugenol diketahui dapat merangsang akar rambut. Formulasi yang mengandung minyak cengkeh ditemukan untuk mengkondisikan rambut dan meningkatkan pertumbuhannya. Itu bisa memperbaiki batang rambut (44). Namun, penelitian lebih lanjut di baris ini diperlukan untuk mencapai kesimpulan lebih lanjut.

11. Mungkin Memiliki Sifat Antikanker

Eugenol diidentifikasi sebagai salah satu agen yang dapat memiliki sifat antikanker. Ini juga dapat mencegah proliferasi sel kanker dan dapat membantu kematian sel kanker (apoptosis) (45).

Dalam penelitian lain, eugenol bisa menekan pertumbuhan melanoma atau kanker kulit. Pengobatan eugenol dapat mengurangi ukuran tumor hingga 40% dan juga memperlambat pertumbuhan tumor (46). Program Toksikologi Nasional berdasarkan beberapa studi karsinogenisitas jangka panjang menyimpulkan bahwa eugenol tidak bersifat karsinogenik pada tikus (47). Pengamatan serupa bisa diharapkan pada manusia juga.

Dalam penelitian lain, ekstrak cengkeh ditemukan dapat menghambat pertumbuhan tumor. Ini bisa menjadi pengobatan baru untuk kanker kolorektal (48).

Namun, penting untuk berhati-hati, karena eugenol mungkin juga memiliki sifat prooksidan tertentu. Senyawa tersebut dapat menyebabkan alergi dan reaksi inflamasi lainnya (49).

12. Dapat Bertindak Sebagai Afrodisiak

In studies on male mice, extracts of clove (along with nutmeg) could enhance sexual behavior (50). In another study, 50% ethanolic extract of clove produced a significant and sustained increase in the sexual activity of normal male rats. The extract also caused no adverse effects (51). However, more studies are warranted in this regard.

These are the major benefits of clove oil. The oil also has other important uses, which we will explore in the following section.

Other Uses of Clove Oil

  • Clove oil blended with cinnamon, orange, nutmeg, or vanilla oils can lift one’s spirits. Using this warming blend in a diffuser will soon fill the room and may also relieve stress.
  • Anecdotal evidence suggests that sniffing the spicy aroma of cloves reduces drowsiness and fatigue, irritability, and headaches. It may stimulate the mind and also increase memory recall.
  • Cloves encourage the loosening of phlegm from the respiratory system. They also promote sweating during fevers, colds, and flu, which can be very healing. Clove oil is often used in remedies for coughs.
  • Like many culinary spices, clove may help relax the smooth muscle lining of the digestive tract. A few drops of the oil in water can relieve nausea. Clove tea may help treat diarrhea, gas, bloating, and intestinal spasms.
  • Clove oil stimulates circulation and blood flow to the skin. This may help those with cold extremities.
  • Clove oil is as effective as oil of oregano in treating athlete’s foot, nail fungus, and other skin problems. It can be applied directly to the skin or nails (unless the skin is sensitive or broken, wherein it must be diluted with extra virgin olive oil or unrefined coconut oil).
  • One drop of clove oil applied to the roof of the mouth may relieve headaches. However, more research is warranted in this regard.
  • Clove oil is long used in aromatherapy to relieve pain. For general pain relief, add 3 drops of clove oil to 1 teaspoon of coconut oil or extra virgin olive oil. Apply it to the pain areas.
  • A band-aid soaked in a few drops of clove oil can help treat warts. Applying the band-aid to warts may help dissolve them if done regularly for a few weeks.

Clove oil is popularly known as a remedy for toothache. Using oil to relieve tooth pain is simple. Check the following section

How To Use Clove Oil To Treat A Toothache?

Dentists use clove oil as an oral anesthetic and also to disinfect root canals. The oil stops the toothache when dropped into the oral cavity. For temporary relief, dip a cotton swab in clove oil and apply it to the affected tooth. Adding a clove or two to a cup of tea can work miracles on a toothache.

Here is how you can use clove oil to relieve your toothache:

  • Dilute a few drops of clove oil in an edible carrier oil, such as olive or coconut oils.
  • Dab a clean cotton ball into the solution, and allow it to soak in it.
  • Avoiding contact with your gums, apply the cotton ball to the sore tooth. It may take a few minutes of application for you to feel the relief.
  • Apply every 2 hours or as necessary.

You can use clove oil in various other ways to achieve its benefits. In the following section we have discussed its most popular uses.

How To Use Clove Oil?

Spray

Using the clove oil as a spray is an easy way to add the clove scent to your room. Clove oil possesses antimicrobial properties, and you can also use it as a mild disinfectant.

To make a clove spray:

  • Add several drops of clove oil to water. You would need 10 to 15 drops of clove oil per ounce of water to prepare the spray.
  • Add it to a spray bottle. Be sure to shake the bottle well before spraying.

Diffuser

You can also use the oil in a diffuser. While diffusing clove oil, carefully follow the instructions that come with the diffuser. Make sure the room is well-ventilated when you diffuse the clove oil.

Topically

You can apply clove oil to your skin to achieve different benefits.

Massage oils

Use 15 drops of clove oil per ounce of carrier oil to create a 2.5 percent solution of massage oil. This solution can be used as a massage oil for pain relief.

Creams, scrubs, or lotions

For use on normal skin, you need 1 to 2.5 percent dilution of clove oil. For sensitive skin, you need 0.5 to 1 percent dilution of the oil. This diluted solution has no aroma and can be used in the preparation of several scrubs, lotions, or creams.

How Do You Use Clove Oil For Hair Growth?

There is not enough information in this regard. But anecdotal evidence suggests that clove oil acts as a natural remedy to promote hair growth as it contains a number of vital vitamins and minerals. Massaging diluted clove oil into your scalp may boost blood circulation. This could ensure more nutrients and oxygen are supplied to your scalp and hair follicles. To experience the benefits of clove essential oil for hair growth, you can indulge in a hot oil treatment or apply a DIY hair mask prepared with clove oil.

Though clove oil is well studied for its benefits, it may not be suitable for all. The oil may cause side effects in some.

Are There Any Side Effects Of Using Clove Oil?

Clove oil may cause local irritation, rare allergic reactions, and contact dermatitis in some individuals. More severe effects include tissue injury and acute onset of seizures, coma, and damage to the liver and kidneys (52). Clove essential oil is generally recognized as a safe substance when consumed in concentrations lower than 1500 mg/kg. The World Health Organization (WHO) established that the daily quantity acceptable of clove per day is 2.5 mg for every kg of body weight in humans (53).

Hepatotoxicity

High doses of eugenol may harm the liver and kidneys, as per some rat studies. Several instances of severe acute liver and kidney injury have been reported after an accidental overdose of eugenol containing herbal products, largely in infants (54), (55).

May Cause Skin irritation

Excess usage of clove oil can cause skin irritation in some people. Eugenol is an effective substance that is incorporated into many dental products. Contact dermatitis due to this chemical is not unusual. However, true serious allergic reactions are extremely rare (56).

As a primary irritant and sensitizer, eugenol is known to cause contact urticaria as well as chronic urticaria (rashes with dangerous swelling) (57). If you are concerned about your sensitivity to this essential oil, do a patch test before using it. Apply a small amount of diluted clove oil to the inside of your elbow. If you notice signs of skin irritation, like redness, itching, or swelling, don’t use clove oil topically.

May Cause Allergies

It is very rare to have an allergic reaction due to clove oil. The eugenol in the oil may cause oral irritation and heat sensation on the tongue (58).

Drug Interactions

Medications that slow blood clotting (anticoagulant/antiplatelet drugs) interact with clove. Hence, avoid using clove oil if you are taking any anticoagulants. Acetyl eugenol, a component of clove oil (Syzygium aromaticum L.), inhibits platelet aggregation in humans. This could lead to bleeding (59), (60).

Avoid using clove oil if you have had a recent major surgery, peptic ulcers, or bleeding disorders, such as hemophilia.

You can buy clove oil from your nearest health store. But before you make a purchase, you need to keep a few things in mind.

What To Look For When Buying Clove Oil

Look for a purity statement on the label

Try to buy 100 percent clove essential oil and look for other ingredients listed (if any).

Don’t go by the marketing hype

Generally, essential oils are not regulated by the Food and Drug Administration (FDA) in the same way as drugs. Hence, you should be more cautious of any oil that claims to cure a specific condition.

Make sure the clove oil is in a dark glass bottle

Light has the potential to damage essential oils. Dark glass helps keep the light out. Always ensure your product comes packaged in a dark glass bottle.

If you can, smell it before buying it

Clove essential oil has a unique fragrance. Smell it before buying. If it does not smell natural, avoid purchasing it.

Conclusion

Clove oil possesses many therapeutic properties and has several health benefits. From dealing with dental problems to treating cardiovascular issues, this essential oil can improve human health in various ways. However, excess usage may cause several side effects. Hence, limit its use and consult your doctor if you experience any adverse effects.

Expert’s Answers For Readers’ Questions

Can you drink clove oil?

Ingestion of clove oil can be dangerous. Clove oil ingestion may result in coma, fits, and acute liver damage (61).

Can clove oil damage teeth?

Clove oil is generally considered safe for teeth.

How often can I use clove oil on my tooth?

If you are suffering from toothache, you can use it every 3-5 hours for relief. If you have multiple pain points in your mouth after a dental procedure, you can add a few drops of clove oil to coconut oil and swirl it in your mouth.

Does clove oil help you sleep?

The oil contains eugenol that is a mild anesthetic. It may aid in sleeping. Apply a few drops of warm clove oil with some carrier oil on your forehead for better sleep.

Can you apply clove oil directly to the skin?

First, do a patch test after diluting the oil with a carrier oil. If there is no reaction, you can apply clove oil to your skin.

How long does clove oil take to work?

Clove oil may soothe a toothache and relieve pain within minutes. It generally takes 5-10 minutes to work.

61 sources

Stylecraze memiliki panduan sumber yang ketat dan bergantung pada studi peer-review, lembaga penelitian akademis, dan asosiasi medis. Kami menghindari penggunaan referensi tersier. Anda dapat mempelajari lebih lanjut tentang bagaimana kami memastikan konten kami akurat dan terkini dengan membaca kebijakan editorial kami.

  • Milind, Parle, dan Khanna Deepa. “Cengkeh: bumbu juara.” Int J Res Ayurveda Pharm 2.1 (2011): 47-54.

    www.researchgate.net/publication/267402397_Clove_A_champion_spice

  • Cortés-Rojas, Diego Francisco dkk. “Cengkeh (Syzygium aromaticum): bumbu yang sangat berharga.” Jurnal Asia Pasifik dari biomedis tropis vol. 4,2 (2014): 90-6.

    www.ncbi.nlm.nih.gov/pmc/articles/PMC3819475/

  • Kumarswamy, A. “Multimodal management of dental pain with focus on alternative medicine: A novel herbal dental gel.” Contemporary clinical dentistry vol. 7,2 (2016): 131-9.

    www.ncbi.nlm.nih.gov/pmc/articles/PMC4906852/

  • Kozam, George. “The effect of eugenol on nerve transmission.” Oral Surgery, Oral Medicine, Oral Pathology 44.5 (1977): 799-805.

    www.sciencedirect.com/science/article/abs/pii/0030422077903905

  • Kothiwale, Shaila V., et al. “A comparative study of antiplaque and antigingivitis effects of herbal mouthrinse containing tea tree oil, clove, and basil with commercially available essential oil mouthrinse.” Journal of Indian Society of Periodontology 18.3 (2014): 316.

    www.ncbi.nlm.nih.gov/pmc/articles/PMC4095623/

  • Kouidhi, Bochra, Tarek Zmantar, and Amina Bakhrouf. “Anticariogenic and cytotoxic activity of clove essential oil (Eugenia caryophyllata) against a large number of oral pathogens.” Annals of microbiology 60.4 (2010): 599-604.

    link.springer.com/article/10.1007/s13213-010-0092-6

  • Marya, Charu M et al. “In vitro inhibitory effect of clove essential oil and its two active principles on tooth decalcification by apple juice.” International journal of dentistry vol. 2012 (2012): 759618.

    www.ncbi.nlm.nih.gov/pmc/articles/PMC3432374/

  • Kanth, M Rajini et al. “Efficacy of Specific Plant Products on Microorganisms Causing Dental Caries.” Journal of clinical and diagnostic research: JCDR vol. 10,12 (2016): ZM01-ZM03. doi:10.7860/JCDR/2016/19772.9025

    www.ncbi.nlm.nih.gov/pmc/articles/PMC5296592/

  • Fu, YuJie, et al. “The antibacterial activity of clove essential oil against Propionibacterium acnes and its mechanism of action.” Archives of dermatology 145.1 (2009): 86-88.

    jamanetwork.com/journals/jamadermatology/article-abstract/711838

  • Ibrahim IM, Elsaie ML, Almohsen AM, Mohey-Eddin MH. Effectiveness of topical clove oil on symptomatic treatment of chronic pruritus. J Cosmet Dermatol. 2017;16(4):508‐511.

    pubmed.ncbi.nlm.nih.gov/28382655/

  • Elwakeel HA, Moneim HA, Farid M, Gohar AA. Clove oil cream: a new effective treatment for chronic anal fissure. Colorectal Dis. 2007;9(6):549‐552.

    pubmed.ncbi.nlm.nih.gov/17573751/

  • Nethravathi, V., and V. Vijaitha. “Effectiveness of Clove oil massage on Lower Back Pain among Post Natal Mothers at Selected Hospitals, Bangalore.” Asian Journal of Nursing education and research 5.4 (2015): 467-470.

    www.researchgate.net/publication/286523804_Effectiveness_of_Clove_oil_massage_on_Lower_Back_Pain_among_Post_Natal_Mothers_at_Selected_Hospitals_Bangalore

  • Cortés-Rojas, Diego Francisco et al. “Clove (Syzygium aromaticum): a precious spice.” Asian Pacific journal of tropical biomedicine vol. 4,2 (2014): 90-6. doi:10.1016/S2221-1691(14)60215-X

    www.ncbi.nlm.nih.gov/pmc/articles/PMC3819475/#b30

  • Li, Hai Ying et al. “Eugenol Inhibits ATP-induced P2X Currents in Trigeminal Ganglion Neurons.” The Korean journal of physiology & pharmacology: official journal of the Korean Physiological Society and the Korean Society of Pharmacology vol. 12,6 (2008): 315-21. doi:10.4196/kjpp.2008.12.6.315

    www.ncbi.nlm.nih.gov/pmc/articles/PMC2788653/

  • Halder, Sumita, et al. “Acute effect of essential oil of Eugenia caryophyllata on cognition and pain in mice.” Naunyn-Schmiedeberg’s archives of pharmacology 385.6 (2012): 587-593.

    link.springer.com/article/10.1007%2Fs00210-012-0742-2

  • Alqareer A, Alyahya A, Andersson L. The effect of clove and benzocaine versus placebo as topical anesthetics. J Dent. 2006;34(10):747‐750.

    pubmed.ncbi.nlm.nih.gov/16530911/

  • Duarte, R. C., et al. “Irradiation effect on antifungal potential of clove essential oil.” Science And Technology Against Microbial Pathogens: Research, Development and Evaluation. 2011. 236-240.

    www.worldscientific.com/doi/abs/10.1142/9789814354868_0046

  • Santin JR, Lemos M, Klein-Júnior LC, et al. Gastroprotective activity of essential oil of the Syzygium aromaticum and its major component eugenol in different animal models. Naunyn Schmiedebergs Arch Pharmacol. 2011;383(2):149‐158.

    pubmed.ncbi.nlm.nih.gov/21140134/

  • Kumaravelu, Parasakthy, et al. “The antioxidant effect of eugenol on CCl4-induced erythrocyte damage in rats.” The Journal of Nutritional Biochemistry 7.1 (1996): 23-28.

    www.sciencedirect.com/science/article/abs/pii/095528639500162X

  • Abdel-Magied, N., and A. G. Ahmed. “Efficacy of clove oil as an antioxidant against radiation risk in male rats.” Journal of Radiation Research and Applied Sciences 4.3 (2011): 939-955.

    inis.iaea.org/search/search.aspx?orig_q=RN:44083430

  • Humbal, Brijesh R., et al. “Evaluation of in-vivo anti-inflammatory activity of Syzygium aromaticum oil in male wistar rats.” (2019).

    www.researchgate.net/publication/334735954_Evaluation_of_in-vivo_anti-inflammatory_activity_of_Syzygium_aromaticum_oil_in_male_wistar_rats

  • Taher, Yousef A., et al. “Experimental evaluation of anti-inflammatory, antinociceptive and antipyretic activities of clove oil in mice.” Libyan Journal of Medicine 10.1 (2015): 28685.

    www.tandfonline.com/doi/full/10.3402/ljm.v10.28685

  • Nuñez, L, and M D’ Aquino. “Microbicide activity of clove essential oil (Eugenia caryophyllata).” Brazilian journal of microbiology: [publication of the Brazilian Society for Microbiology] vol. 43,4 (2012): 1255-60.

    www.ncbi.nlm.nih.gov/pmc/articles/PMC3769004/

  • Ács, Kamilla et al. “Antibacterial activity evaluation of selected essential oils in liquid and vapor phase on respiratory tract pathogens.” BMC complementary and alternative medicine vol. 18,1 227. 27 Jul. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6064118/
  • Santa Packyanathan, Jerusha, and Gopinath Prakasam. “Antibacterial Effect of Clove Oil against Clinical Strains of Escherichia coli.” Journal of Pharmaceutical Sciences and Research 9.7 (2017): 1203.

    search.proquest.com/openview/8bf3b96982be7f97c4f86c4dd8ae3dd9/1?pq-origsite=gscholar&cbl=54977

  • Vázquez-Sánchez D, Cabo ML, Rodríguez-Herrera JJ. Antimicrobial activity of essential oils against Staphylococcus aureus biofilms. Food Sci Technol Int. 2015;21(8):559‐570.

    pubmed.ncbi.nlm.nih.gov/25280938/

  • Chami N, Bennis S, Chami F, Aboussekhra A, Remmal A. Study of anticandidal activity of carvacrol and eugenol in vitro and in vivo. Oral Microbiol Immunol. 2005;20(2):106‐111.

    pubmed.ncbi.nlm.nih.gov/15720571/

  • Kurokawa M, Nagasaka K, Hirabayashi T, et al. Efficacy of traditional herbal medicines in combination with acyclovir against herpes simplex virus type 1 infection in vitro and in vivo. Antiviral Res. 1995;27(1-2):19‐37.

    pubmed.ncbi.nlm.nih.gov/7486956/

  • Wu, Shuhua et al. “Protective essential oil attenuates influenza virus infection: an in vitro study in MDCK cells.” BMC complementary and alternative medicine vol. 10 69. 15 Nov. 2010.

    www.ncbi.nlm.nih.gov/pmc/articles/PMC2994788/

  • Shapiro, Rochel. “Prevention of vector transmitted diseases with clove oil insect repellent.” Journal of pediatric nursing 27.4 (2012): 346-349.

    www.sciencedirect.com/science/article/abs/pii/S0882596311001898

  • Iwamatsu, Takuma, et al. “Identification of repellent odorants to the body louse, Pediculus humanus corporis, in clove essential oil.” Parasitology research 115.4 (2016): 1659-1666.

    link.springer.com/article/10.1007/s00436-016-4905-9

  • Park, Il-Kwon, and Sang-Chul Shin. “Fumigant activity of plant essential oils and components from garlic (Allium sativum) and clove bud (Eugenia caryophyllata) oils against the Japanese termite (Reticulitermes speratus Kolbe).” Journal of Agricultural and Food Chemistry 53.11 (2005): 4388-4392.

    pubs.acs.org/doi/abs/10.1021/jf050393r

  • Eamsobhana P, Yoolek A, Kongkaew W, et al. Laboratory evaluation of aromatic essential oils from thirteen plant species as candidate repellents against Leptotrombidium chiggers (Acari: Trombiculidae), the vector of scrub typhus. Exp Appl Acarol. 2009;47(3):257‐262.

    pubmed.ncbi.nlm.nih.gov/19009361/

  • Hanifah, Azima Laili, et al. “Laboratory evaluation of six crude plant extracts as repellents against larval Leptotrombidium deliense (Acari: Trombiculidae).” Asian Pacific Journal of Tropical Biomedicine 2.1 (2012): S257-S259.

    www.sciencedirect.com/science/article/abs/pii/S2221169112601701

  • Sritabutra, Duangkamon, et al. “Evaluation of herbal essential oil as repellents against Aedes aegypti (L.) and Anopheles dirus Peyton & Harrion.” Asian Pacific Journal of Tropical Biomedicine 1.1 (2011): S124-S128.

    www.sciencedirect.com/science/article/abs/pii/S222116911160138X

  • Barbosa, Juliana DF, et al. “Structure–activity relationships of eugenol derivatives against Aedes aegypti (Diptera: Culicidae) larvae.” Pest management science 68.11 (2012): 1478-1483.

    onlinelibrary.wiley.com/doi/abs/10.1002/ps.3331

  • Kafle L, Shih CJ. Toxicity and repellency of compounds from clove (Syzygium aromaticum) to red imported fire ants Solenopsis invicta (Hymenoptera: Formicidae). J Econ Entomol. 2013;106(1):131‐135.

    pubmed.ncbi.nlm.nih.gov/23448024/

  • Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Eugenol (Clove Oil) [Updated 2019 Oct 28].

    www.ncbi.nlm.nih.gov/books/NBK551727/

  • Peixoto-Neves, Dieniffer et al. “Eugenol dilates rat cerebral arteries by inhibiting smooth muscle cell voltage-dependent calcium channels.” Journal of cardiovascular pharmacology vol. 64,5 (2014): 401-6.

    www.ncbi.nlm.nih.gov/pmc/articles/PMC4224997/

  • Lahlou, Saad, et al. “Cardiovascular effects of eugenol, a phenolic compound present in many plant essential oils, in normotensive rats.” Journal of cardiovascular pharmacology 43.2 (2004): 250-257.

    www.researchgate.net/publication/8925226_Cardiovascular_Effects_of_Eugenol_A_Phenolic_Compound_Present_in_Many_Plant_Essential_Oils_in_Normotensive_Rats

  • Al-Okbi, Sahar Y., et al. “Protective effect of clove oil and eugenol microemulsions on fatty liver and dyslipidemia as components of metabolic syndrome.” Journal of medicinal food 17.7 (2014): 764-771.

    pubmed.ncbi.nlm.nih.gov/24611461/

  • Shukri, Radhiah, Suhaila Mohamed, and Noordin Mohamed Mustapha. “Cloves protect the heart, liver and lens of diabetic rats.” Food chemistry 122.4 (2010): 1116-1121.

    www.sciencedirect.com/science/article/abs/pii/S0308814610003870

  • Peixoto‐Neves, Dieniffer, et al. “Eugenol dilates mesenteric arteries and reduces systemic BP by activating endothelial cell TRPV 4 channels.” British journal of pharmacology 172.14 (2015): 3484-3494.

    pubmed.ncbi.nlm.nih.gov/25832173/

  • Shahtalebi, Mohammad Ali, Atefeh Sadat-Hosseini, and Leila Safaeian. “Preparation and evaluation of clove oil in emu oil self-emulsion for hair conditioning and hair loss prevention.” Journal of HerbMed Pharmacology 5 (2016).

    www.researchgate.net/publication/301204003_Preparation_and_evaluation_of_clove_oil_in_emu_oil_self-emulsion_for_hair_conditioning_and_hair_loss_prevention

  • Aggarwal BB, Shishodia S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol. 2006;71(10):1397‐1421.

    pubmed.ncbi.nlm.nih.gov/16563357/

  • Ghosh, Rita, et al. “Eugenol Causes Melanoma Growth Suppression through Inhibition of E2F1 Transcriptional Activity.” Journal of Biological Chemistry, 18 Feb. 2005, www.jbc.org/content/280/7/5812.short.
  • National Toxicology Program. Carcinogenesis Studies of Eugenol (CAS No. 97-53-0) in F344/N Rats and B6C3F1 Mice (Feed Studies). Natl Toxicol Program Tech Rep Ser. 1983;223:1‐159.

    pubmed.ncbi.nlm.nih.gov/12778213/

  • Liu, Haizhou et al. “Clove extract inhibits tumor growth and promotes cell cycle arrest and apoptosis.” Oncology research vol. 21,5 (2014): 247-59.

    www.ncbi.nlm.nih.gov/pmc/articles/PMC4132639/

  • Atsumi, T., et al. “A Comparative Study of the Antioxidant/Prooxidant Activities of Eugenol and Isoeugenol with Various Concentrations and Oxidation Conditions.” Toxicology in Vitro, Pergamon, 17 June 2005, www.sciencedirect.com/science/article/abs/pii/S088723330500072X.

    www.citationmachine.net/bibliographies/616422860?new=true

  • Tajuddin et al. “Aphrodisiac activity of 50% ethanolic extracts of Myristica fragrans Houtt. (nutmeg) and Syzygium aromaticum (L) Merr. & Perry. (clove) in male mice: a comparative study.” BMC complementary and alternative medicine vol. 3 6. 20 Oct. 2003.

    www.ncbi.nlm.nih.gov/pmc/articles/PMC270058/

  • Tajuddin et al. “Effect of 50% ethanolic extract of Syzygium aromaticum (L.) Merr. & Perry. (clove) on sexual behaviour of normal male rats.” BMC complementary and alternative medicine vol. 4 17. 5 Nov. 2004.

    www.ncbi.nlm.nih.gov/pmc/articles/PMC534794/

  • Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Eugenol (Clove Oil) [Updated 2019 Oct 28].

    www.ncbi.nlm.nih.gov/books/NBK551727/

  • Gülçin, İlhami, et al. “Antioxidant Activity of Clove Oil – A Powerful Antioxidant Source.” Arabian Journal of Chemistry, Elsevier, 19 Sept. 2010, www.sciencedirect.com/science/article/pii/S1878535210001899.
  • Thompson DC, Constantin-Teodosiu D, Moldéus P. Metabolism and cytotoxicity of eugenol in isolated rat hepatocytes. Chem Biol Interact. 1991;77(2):137‐147.

    pubmed.ncbi.nlm.nih.gov/1991333/

  • Mizutani T, Satoh K, Nomura H, Nakanishi K. Hepatotoxicity of eugenol in mice depleted of glutathione by treatment with DL-buthionine sulfoximine. Res Commun Chem Pathol Pharmacol. 1991;71(2):219‐230.

    pubmed.ncbi.nlm.nih.gov/2047567/

  • Barkin ME, Boyd JP, Cohen S. Acute allergic reaction to eugenol. Oral Surg Oral Med Oral Pathol. 1984;57(4):441‐442.

    pubmed.ncbi.nlm.nih.gov/6584843/

  • Tammannavar P, Pushpalatha C, Jain S, Sowmya SV. An unexpected positive hypersensitive reaction to eugenol. BMJ Case Rep. 2013;2013:bcr2013009464. Published 2013 Sep 18.

    pubmed.ncbi.nlm.nih.gov/24049087/

  • Klein AH, Carstens MI, Carstens E. Eugenol and carvacrol induce temporally desensitizing patterns of oral irritation and enhance innocuous warmth and noxious heat sensation on the tongue. Pain. 2013;154(10):2078‐2087.

    pubmed.ncbi.nlm.nih.gov/23791894/

  • Srivastava, K. C., and N. Malhotra. “Acetyl Eugenol, a Component of Oil of Cloves (Syzygium Aromaticum L.) Inhibits Aggregation and Alters Arachidonic Acid Metabolism in Human Blood Platelets.” Prostaglandins, Leukotrienes and Essential Fatty Acids, Churchill Livingstone, 3 Apr. 2004.

    www.sciencedirect.com/science/article/abs/pii/095232789190070L

  • Srivastava, K. C. “Antiplatelet Principles from a Food Spice Clove (Syzgium Aromaticum L).” Prostaglandins, Leukotrienes and Essential Fatty Acids, Churchill Livingstone, 3 Apr. 2004.

    www.sciencedirect.com/science/article/abs/pii/095232789390116E

  • Hartnoll G, Moore D, Douek D. Near fatal ingestion of oil of cloves. Arch Dis Child. 1993;69(3):392‐393.

    pubmed.ncbi.nlm.nih.gov/8215554/

Direkomendasikan:

Artikel yang menarik
11 Serum Rambut Terbaik Tersedia Di India 2020
Baca Lebih Lanjut

11 Serum Rambut Terbaik Tersedia Di India 2020

Tahukah Anda perasaan yang Anda dapatkan saat menyisir rambut yang baru dipotong? Rasanya begitu lembut dan halus, dan Anda bersumpah pada diri sendiri bahwa Anda akan melakukan semua yang diperlukan untuk menjaganya tetap seperti itu sampai janji temu berikutnya

Perfectly Messy - 50 Gaya Rambut Berantakan Yang Berbeda
Baca Lebih Lanjut

Perfectly Messy - 50 Gaya Rambut Berantakan Yang Berbeda

Anda bisa memakai model rambut yang berantakan dan tidak terawat untuk acara karpet merah atau ke pesta rumah sederhana. Dari kuncir kuda yang berantakan hingga kepang bahkan pixies, banyak sekali pilihan untuk gaya yang tidak disesuaikan. Tidak perlu produk penataan gaya apa pun untuk menjaga gaya tetap kencang

70 Pretty Updos Untuk Rambut Pendek -
Baca Lebih Lanjut

70 Pretty Updos Untuk Rambut Pendek -

Apakah Anda selalu merasa bingung saat menata rambut pendek Anda? Ingin tahu bagaimana menata rambut pendek? Nah, gaya rambut pendek tidak selalu berarti bob tumpul atau kuncir kuda tinggi. Anda juga bisa mengenakan dos cantik dan terlihat menggairahkan dari semua aspek